A participação da glicogênio sintase cinase 3 na modulação de vias hipertróficas musculares e as influências exercidas pelo exercí­cio de forças nestas sinalizações

  • Bruno Gil Aldenucci Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Fisioterapeuta e Mestrando do Programa de Biologia Celular e Molecular, na área de concentração de Fisiologia Humana, da Universidade Federal do Paraná
  • Luis Fernando Hoinaski Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Bacharel em Educação Fí­sica pela Pontifí­cia Universidade Católica do Paraná
  • Everson Araújo Nunes Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Doutor pelo Programa de Biologia Celular e Molecular pela Universidade Federal do Paraná
Palavras-chave: Exercício de força, Hipertrofia, Glicogênio Sintase cinase 3, Proteína cinase B (Akt)

Resumo

Objetivo: Objetivo do presente trabalho é revisar quais as influências da Glicogênio Sintase Cinase 3 na modulação de vias hipertróficas musculares exercidas pelo exercício de força. Revisão de Literatura: A glicogênio sintase cinase 3 (GSK-3) é uma serina/treonina presente em todososeucarióticos. Regula várias funções celulares, incluindo desenvolvimento, metabolismo, expressão gênica, tradução protéica, organização do citoesqueleto, regulação do ciclo celular, e apoptose. Adicionalmente é regulador negativo tanto do crescimento patológico como normal. É inibida por vias como da fosfatidilinositol-3-cinase/Proteína cinase B (também denominada Akt). Durante o exercício físico a atividade da Akt é aumentada significativamente, inibindo a GSK-3. A GSK-3 exerce influência negativa sobre fatores transcricionais como: fator nuclear de células T ativadas (NFAT), β-catenina e fator de iniciação de eucarióticos 2B (eIF2B), os quais estimulam síntese protéica e conseqüente hipertrofia muscular. Conclusão: Entender os mecanismos de sinalização que controlam o desenvolvimento do músculo esquelético auxilia na formação de tratamentos para doenças catabólicas, desordens neuromusculares, podendo reduzir também o tempo de reabilitação pós-trauma músculo-esquelético.

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Publicado
2011-12-31
Como Citar
Aldenucci, B. G., Hoinaski, L. F., & Nunes, E. A. (2011). A participação da glicogênio sintase cinase 3 na modulação de vias hipertróficas musculares e as influências exercidas pelo exercí­cio de forças nestas sinalizações. RBPFEX - Revista Brasileira De Prescrição E Fisiologia Do Exercício, 4(19). Recuperado de https://www.rbpfex.com.br/index.php/rbpfex/article/view/227
Edição
v. 4 n. 19 (2010)
Seção
Artigos Científicos - Original

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