Potencial mechanisms of resistance training action upon cachexia in cancer patients
Abstract
Cachexia is a condition characterized by hipercatabolism (e.g. involuntary weight loss) that can occur in some types of cancer. This reduction in lean body mass contributes to increased morbidity and mortality in cancer patients. So, interventions that can preserve muscle mass are critical to improve cancer patients ́ quality of life. A series of studies haveshown that exercise can minimize the loss of muscle mass in AIDS, diabetes or in atrophy by disuse. Among exercise models, resistance training presents a special interest since it can preserve and/or increase muscle mass. Nevertheless, the mechanisms by means resistance training acts are not well known. The aim of this review was to evaluate the mechanisms involved in the effects of resistance training on cancer patients. The literature showed that these effects are a consequence of the increased protein synthesis promoted by hormones and cytokines. In the future, the better understanding about these mechanisms could be used to proper exercise prescription to cancer patients.
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