Oxidative stress parameters in mice submitted to swimming training and overtraining
Abstract
The aim of this study was to compare oxidative stress levels in mice (Balb-C) submitted to two different training conditions: moderate and progressive training (training group, T-G) and overtraining condition (G-OVER). We investigated some markers of oxidative stress, such as plasma thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC) and sulfhydryl groups (GSH) and the antioxidant enzymes catalase (CAT) and glutathione reductase (GR) in hemolysate. As markers of cell damage was quantified plasma creatine kinase (CK) and aspartate transferase (AST) concentrations; were also observed patterns of physiological changes by quantifying plasma creatinine (CRE) and urea (UR). As the most important results, it was observed that in G-OVER a significant decrease of CAT and GR (p<0.001) compared to G-T, as well as significant increases in TBARS, PC and CK (p<0.01) and AST, CRE and UR (p<0.001) compared to G-T. We concluded that changes in cellular redox state can be an important object of study for overtraining detection.
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