Subclinical inflammation and cardiovascular disease in obesity: the role of continuous and interval exercise as treatment
Abstract
In recent decades the adipose tissue was seen as an endocrine organ, leaving his status simply estocador energy. The consensus is that adipose tissue release of acute phase inflammatory cytokines, which may increase the risk of cardiovascular diseases. Some studies have shown that physical exercise is an important resource for the treatment of obesity and can decrease the inflammatory state in obese individuals, however, is not well described what kind of exercise or intensity. Recentstudies have shown probable benefits of high intensity activities, predominantly anaerobic in fat oxidation capacity. However, the effect of predominantly anaerobic exercise in reducing obesity and inflammatory status is still unknown. Thus, the objectiveof this study was to synthesize the information about the evidence of exercise, with predominantly aerobic or anaerobic and impact grade inflammation in obese state.
References
-Abeso, A. B. P. O. E. D. O. E. D. S. M.-. Diretrizes brasileiras de obesidade 2009/2010. Itapevi, SP: AC Farmacêutica: p. 1-85. 2009.
-Arsenault, B. J.; e colaboradores. Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure. Atherosclerosis. Vol. 207. Núm. 2. p. 530-533. 2009.
-Bacha, F.; e colaboradores. Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab. Vol. 88. Núm. 6. p. 2534-2540. 2003.
-Balanescu, S.; e colaboradores. Systemic Inflammation and Early Atheroma Formation: Are They Related? Maedica (Buchar). Vol. 5. Núm. 4. p. 292-301. 2010.
-Barbosa, P. J. B.; e colaboradores. Criteria for central obesity in a Brazilian population: impact on metabolic syndrome. Arq. Bras. Cardiol. Vol. 87. Núm. 4. p. 407-414. 2006.
-Berg, A. H.; Scherer, P. E. Adipose Tissue, Inflammation, and Cardiovascular Disease. Circulation Research. Vol. 96. p. 939-949. 2005.
-Berliner, J. A.; e colaboradores. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. Vol. 91. Núm. 9. p. 2488-2496. 1995.
-Boscaro, M.; Giacchetti, G.; Ronconi, V. Visceral adipose tissue: emerging role of gluco-and mineralocorticoid hormones in the setting of cardiometabolic alterations. Ann N Y Acad Sci. Vol. 1264. Núm. 1. p. 87-102. 2012. ISSN 0077-8923.
-Boutcher, S. H. High-intensity intermittent exercise and fat loss. J Obes. Vol. 2011. p. 868305. 2011.
-Brooks, G. C.; Blaha, M. J.; Blumenthal, R. S. Relation of C-reactive protein to abdominal adiposity. Am J Cardiol. Vol. 106. Núm. 1. p. 56-61. 2010. ISSN 0002-9149.
-Burgomaster, K. A.; e colaboradores. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. Vol. 586. Núm.1. p.151-160. 2008.
-Burgomaster, K. A.; e colaboradores. Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol. Vol. 98. Núm. 6. p. 1985-1990. 2005.
-Campbell, K. L.; e colaboradores. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiol Biomarkers Prev. Vol. 17. Núm. 7. p. 1714-1718. 2008.
-Church, T. S.; e colaboradores. Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc. Vol. 42. Núm. 4. p. 708-716. 2010.
-Coelho, M.; Oliveira, T.; Fernandes, R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. Vol. 9. Núm. 2. p. 191-200. 2013.
-Federation, I. D. The IDF consensus worldwide definition of the metabolic syndrome. 2006.
-Fonseca-Alaniz, M. H.; e colaboradores. The adipose tissue as a regulatory center of the metabolism. Arq Bras Endocrinol Metab. Vol. 50. Núm. 2. p. 216-229. 2006.
-Fruhbeck, G.; e colaboradores. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. Vol. 280. Núm. 6.p.e827-847. 2001.
-Garanty-Bogacka, B. e colaboradores. Changes in Serum Adipocytokines and Inflammatory Biomarkers Following One-Year of Exercise Training in Obese Adolescents. Journal of Diabetes & Metabolism. Vol. 3. Núm.7. p. 1-6. 2012.
-Gibala, M. J.; e colaboradores. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of Physiology. Vol. 590. Núm. 5. p. 1077-1084. 2012.
-Gibala, M. J.; Mcgee, S. L. Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? Exerc Sport Sci Rev. Vol. 36. Núm. 2. p. 58-63. 2008.
-Gomes, F.; e colaboradores. Obesity and coronary artery disease: role of vascular inflammation. Arq. Bras. Cardiol. Vol. 94. Núm. 2. p. 273-279. 2010.
-Haram, P. M.; e colaboradores. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc Res. Vol. 81. Núm. 4. p. 723-732. 2009.
-Haslam, D. W.; James, W. P. Obesity. Lancet. Vol. 366. Núm. 9492. p. 1197-1209. 2005.
-Hermsdorff, H. H. M.; Monteiro, J. B. R. Visceral, subcutaneous or intramuscular fat: where is the problem? Arq Bras Endocrinol Metab. Vol. 48. Núm. 6. p. 803-811. 2004.
-Heydari, M.; Freund, J.; Boutcher, S. H. The effect of high-intensity intermittent exercise on body composition of overweight young males. J Obes. Vol. 2012. p. 480467. 2012.
-Hunter, G. R.; e colaboradores. Exercise training prevents regain of visceral fat for 1 year following weight loss. Obesity (Silver Spring). Vol. 18. Núm. 4. p. 690-695. 2010.
-Hwang, S. J.; e colaboradores. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation. Vol. 96. Núm. 12. p. 4219-4225. 1997.
-IBGE. Pesquisa de Orçamentos Familiares 2008-2009. Antropometria e Estado Nutricional de Crianças, Adolescentes e Adultos no Brasil. 2010.
-Imayama, I.; e colaboradores. Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. Cancer Res. Vol. 72. Núm. 9. p. 2314-2326. 2012.
-Irving, B. A.; e colaboradores. Effect of exercise training intensity on abdominal visceral fat and body composition. Med Sci Sports Exerc. Vol. 40. Núm. 11. p. 1863-1872. 2008.
-Kim, Y.; Lee, S. Physical activity and abdominal obesity in youth. Appl Physiol Nutr Metab. Vol. 34. Núm. 4. p. 571-581. 2009.
-Kondo, T.; Kobayashi, I.; Murakami, M. Effect of exercise on circulating adipokine levels in obese young women. Endocr J. Vol. 53. Núm. 2. p. 189-195. 2006.
-Lagrand, W. K.; e colaboradores. C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? Circulation. Vol. 100. Núm. 1. p. 96-102. 1999.
-Leggate, M.; e colaboradores. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. J Appl Physiol. Vol. 112. Núm. 8. p. 1353-1360. 2012.
-Leite, L. D.; Rocha, E. D. M.; Brandão-Neto, J. Obesidade: uma doença inflamatória. Rev. Ciência & Saúde. Vol. 2. Núm. 2. p. 85-95. 2009.
-Lemieux, I.; e colaboradores. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol. Vol. 21. Núm. 6. p. 961-967. 2001.
-Libby, P. Inflammation in atherosclerosis. Nature. Vol. 420. Núm. 6917. p. 868-874. 2002.
-Libby, P.; Ridker, P. M.; Maseri, A. Inflammation and atherosclerosis. Circulation. Vol. 105. Núm. 9. p. 1135-1143. 2002.
-Lin, J. S.; e colaboradores. Behavioral Counseling to Promote Physical Activity and a Healthful Diet to Prevent Cardiovascular Disease in Adults. 2010.
-Miller, G. D.; e colaboradores. Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr. Vol. 8. Núm. 4. p. 205-211. 2014.
-Moreira, M. M.; e colaboradores. Effects of aerobic and anaerobic exercise on cardiac risk variables in overweight adults. Arq. Bras. Cardiol. Vol. 91. Núm. 4. p. 219-226. 2008.
-Nicklas, B. J.; You, T.; Pahor, M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Cmaj. Vol. 172. Núm. 9. p. 1199-1209. 2005.
-Nielsen, S.; e colaboradores. Splanchnic lipolysis in human obesity. J Clin Invest. Vol.113. Núm. 11. p. 1582-1588. 2004.
-Nijmeijer, R.; e colaboradores. C-Reactive Protein Activates Complement in Infarcted Human Myocardium. Am J Pathol. Vol. 163. Núm.1. p. 269-275. 2003.
-Pou, K. M.; e colaboradores. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. Vol. 116. Núm. 11. p. 1234-1241. 2007.
-Prado, W. L.; e colaboradores. Obesity and inflammatory adipokines: practical implications for exercise prescription. Rev Bras Med Esporte. Vol. 15. Núm. 5. p. 378-383. 2009.
-Ramalho, R.; Guimarães, C. Papel do tecido adiposo e dos macrófagos no estado de inflamação crônica associada a obesidade. Acta Med Port. Vol. 21. p. 489-496. 2008.
-Ridker, P. M.; Cook, N. Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores. Circulation. Vol. 109. Núm. 16. p. 1955-1959. 2004.
-Rocha, V. Z.; Libby, P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. Vol. 6. Núm. 6. p. 399-409. 2009. ISSN 1759-5002.
-Ross, R. Atherosclerosis an inflammatory disease. N Engl J Med. Vol. 340. Núm. 2. p. 115-126. 1999.
-Samjoo, I. A.; e colaboradores. The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. Nutr Diabetes. Vol. 3. p. e88. 2013.
-Santos, W. B.; e colaboradores. Proteína-C-Reativa e Doença Cardiovascular: As Bases da Evidência Científica. Arq Bras Cardiol. Vol. 80. Núm. 4. p. 452-456. 2003.
-Silva, D.; Lacerda, A. P. Proteína C reativa de alta sensibilidade como biomarcador de risco na doença coronária. Rev Port Cardiol. Vol. 31. Núm. 11. p. 733-745. 2012.
-Silva, D. O.; e colaboradores. Proteina C reativa e instabilidade clinica. J. vasc. bras. Vol. 6. Núm. 2. p. 124-129. 2007.
-Silveira, M. R.; e colaboradores. Correlação entre obesidade, adipocinas e sistema imunológico. Rev Bras Cineantropom Desempenho Hum. Vol. 11. Núm. 4. p. 466-472. 2009.
-Sironi, A. M.; e colaboradores. Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat. Hypertension. Vol. 51. Núm. 2. p. 282-288. 2008.
-Stensvold, D.; Slørdahl, S. A.; Wisløff, U. Effect of Exercise Training on Inflammation Status AmongPeople with Metabolic Syndrome. Metabolic Syndrome and Related Disorders. Vol. 10. Núm. 4. p. 267-272. 2012.
-Sá, C. K. C.; e colaboradores. Effects of Interval Training Versus Continuous Exercise on Anthropometric and Cardiorespiratory Fitness Markersin Obese Women. J Nutr Disorders Ther. Vol. S2. Núm. 2. p. 1-5. 2012.
-Talanian, J. L.; e colaboradores. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. Vol. 102. Núm. 4.p.1439-1447. 2007.
-Terada, S.; Tabata, I.; Higuchi, M. Effect of high-intensity intermittent swimming training on fatty acid oxidation enzyme activity in ratskeletal muscle. Jpn J Physiol. Vol. 54. Núm. 1. p. 47-52. 2004.
-Thorogood, A.; e colaboradores. Isolated aerobic exercise and weight loss: a systematic review and meta-analysis of randomized controlled trials. Am J Med. Vol. 124. Núm. 8. p. 747-755. 2011.
-Tjonna, A. E.; e colaboradores. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. Vol. 118. Núm. 4. p. 346-354. 2008.
-Toprak, A.; e colaboradores. C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study). BMC Cardiovasc Disord. Vol. 11. p. 78. 2011.
-Trayhurn, P. Adipocyte biology. Obes Rev. Vol. 8. Suppl. 1. p. 41-44. 2007.
-Visser, M.; e colaboradores. Elevated C-reactive protein levels in overweight and obese adults. Jama. Vol. 282. Núm. 22. p. 2131-2135. 1999.
-Wajchenberg, B. L. Tecido adiposo como glândula endócrina. Arq Bras Endocrinol Metab. Vol. 44. Núm. 1. p. 13-20. 2000.
-WHO. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. Vol. 894. p. i-xii. 1-253. 2000. ISSN 0512-3054. Disponível em: < http://dx.doi.org/ >.
-WHO. World Health Statistics 2009. WHO, 2010. Disponível em: < http://www.who.int/whosis/whostat/2009/en/ >.
-Wiklund, P.; e colaboradores.Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men andwomen. J Clin Endocrinol Metab. Vol. 93. Núm. 11. p. 4360-4366. 2008.
-Wing, R. R.; e colaboradores. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. Vol. 369. Núm. 2. p. 145-154. 2013.
-Yatsuya, H.; e colaboradores. Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study. Int J Obes (Lond). Vol. 35. Núm. 5. p.684-691. 2011.
-Yip, H. K.; e colaboradores. Strong correlation between serum levels of inflammatory mediators and their distribution in infarct-related coronary artery. Circ J. Vol. 70. Núm. 7. p. 838-845. 2006.
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