Immunodulation in experimental model of rheumatoidarthritis submitted to the treatment of paladio omplex and swimming
Abstract
Rheumatoid arthritis (RA) is an autoimmune disorder that leads to joint inflammation affecting bone and cartilage tissues. Metal complexes, including the palladium, have been used in medicine as an alternative for treatment of various diseases. Assess activity of palladium and immune response in experimental models. Cytokines from the immunological system were analyzed and quantified regarding the action of the metal complex palladium associated with swimming practice in arthritic experimental models after 30 days from the induction of RA. 56 male Wistar rats were divided into 14 groups: i. arthritic, that received the RA induction by antigen Mycobacterium sp together with the CFA; and ii. control, submitted or not to swimming three times a week in 30-minute sessions. It is observed that the arthritic groups treated with palladium (G1 and G4) had increased levels of anti-inflammatory cytokine TGF-β. G1 obtained a reduction of pro-inflammatory cytokine IL-4 compared to their control group (G7) due to swimming. Other cytokines (TNF-α and IL1-β), on groups G1 and G4, when compared to the arthritic groups not treated with palladium (G2, G3, G5 and G6), didn't have their levels reduced below their control groups (G7 and G10); however, they responded well to the reduction of TNF-α and IL-1-β comparing arthritic and control groups both not treated with palladium. Therefore, the palladium complex, associated with swimming practice, is a proposition for therapeutic intervention for the rehabilitation of rheumatoid arthritis experimental models.
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