Influence of genetic markers in athletic performance

  • Marcos Viní­cius Farias Centro Universitário UNINOVAFAPI
  • Pedro Paulo de Holanda Barroso Centro Universitário UNINOVAFAPI
  • Paulo Afonso Neiva Cavalcante Centro Universitário UNINOVAFAPI
  • Daniela Moura Parente Doutora em Biotecnologia - Rede Nordeste em Biotecnologia - RENORBIO. Professora do Centro Universitário UNINOVAFAPI

Abstract

The concept that genetic traits are strongly associated with human physical performance has been widely accepted in the last decade. Some studies have shown that certain DNA polymorphisms may be related to sports performance, both in short duration modalities and with a high demand for muscle strength, as well as in long term tests, primarily dependent on aerobic metabolism. DNA polymorphisms are called base sequences that differ from those considered "normal", that is, that they present less frequency in a certain population. Research projects will be analyzed to study the DNA of young athletes in order to elucidate the mechanisms that determine a better execution of certain sports. Genetic studies relate 23 genes capable of influencing the resistance phenotype, of which the Olympic DNA project focuses on two specifically related to physical performance: the alpha-actinin-3 protein (ACTN3) and the angiotensin-converting enzyme (ACE). This project consists of the creation of a biological database for young people between 8 and 18 years old. The main objective of this initiative is to correlate the physical aptitudes of each athlete in order to direct him to the sport in which he would obtain the highest performance. Genetic marker studies confirm that physical fitness is related not only to environmental and nutritional factors, but also to genetic conditions. As is the case of ACTN3 gene polymorphism.

References

-DeMoor, M.H; e colaboradores. Ligação Genome-wide procurar status de atleta em 700 mulheres britânico pares DZ individuais. Gêmeo Res Hum Genet. Vol. 10. p. 812-820. 2007.

-Dias, R.G. Genética, performance física humana e doping genético: o senso comum versus a realidade científica. São Paulo, 2011. Disponível em: <http://www.ciencias.seed.pr.gov.br/modules/noticias/article.php?storyid=846>. Acesso em: 22/09/2016.

-GayagayG.; e colaboradores. Elite endurance athletes and the ACE I allele –the role of genes in athletic performance. Hum Genet. Vol. 103. Num. 1. p. 48-50. 1998.

-Hartly, D.L. Princípios de genética de populações. 3ª Edição. 2008.

-Lippi, G.; Favaloro, E.J.; Guidi, G.C. The genetic basis of human athletic performance. Why are psychological components so often overlooked?J Physiol. Vol. 586. p. 3017-3020. 2008.

-Malina, R. M.; Bouchard, C.; Bor-Or, O. Growth, maturation, and physical activity. Champaign Illinois: Human Kinetics. 2004.

-Meira, T.B.; Nunomura, M. Interação entre leptina, ginástica artística, puberdade e exercício em atletas do sexo feminino. Rev. Bras. Ciênc. Esporte. Vol. 32. Núm. 1. 2010.

-Myburgh, K.H. What makes an endurance athleteworld-class? Not simply a physiological conundrum.Comp Biochem Physiol A Mol Integr Physiol. Vol. 136. Núm. 1. p. 171-90. 2003.

-Rodrigues, C.F.A.; Fillus, I.C.; Correlação genética de aptidão para modalidades esportivas específicas: considerações bioéticas. Rev. Bioét. Vol. 23.Núm. 2. 2015.

-Ruiz, J.R.; e colaboradores. The -174 G/C polymorphism of the IL6 gene is associated with elite Power performance. J Sci Med Sport. Vol. 13. Núm. 5. p. 549-53. 2009.

-Yngvadottir, B.; e colaboradores. A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs. Am J Hum Genet. Vol. 84. Núm. 2. p. 224-234. 2009.

Published
2017-09-01
How to Cite
Farias, M. V., de Holanda Barroso, P. P., Neiva Cavalcante, P. A., & Parente, D. M. (2017). Influence of genetic markers in athletic performance. Brazilian Journal of Exercise Prescription and Physiology, 11(68), 626-630. Retrieved from https://www.rbpfex.com.br/index.php/rbpfex/article/view/1233
Section
Scientific Articles - Review