The role of physical exercise in the tumor necrosis factor alfa in ankylosing spondylitis carriers

  • Camila Contini Paraschiva Programa de Pós-graduação Lato Sensu em Fisiologia do Exercí­cio - Prescrição do Exercí­cio da Universidade Gama Filho - UGF. Unime - União Metropolitana de Educação e Cultura, cursando.
  • Tâmara Lopes Silva Programa de Pós-graduação Lato Sensu em Fisiologia do Exercí­cio - Prescrição do Exercí­cio da Universidade Gama Filho - UGF. Universidade Católica do Salvador - UcSal
  • Vanessa Vilas Boas Lima Programa de Pós-graduação Lato Sensu em Fisiologia do Exercí­cio - Prescrição do Exercí­cio da Universidade Gama Filho - UGF. Universidade Católica do Salvador - UcSal
Keywords: Ankylosing spondylitis, TNF-alpha, Physical exercise, TNF-alpha inhibitors

Abstract

Ankylosing Spondylitis is a chronic inflammatory rheumatic disease in which the pro inflammatory cytokine TNF-alpha has a key role in its pathogenesis, leading to a structural and functional loss to their carriers and the reduction of the quality of life. Therefore, the therapeutic anti-TNF-alpha has been showing efficiency in reducing the inflammatory activity and in the damage reduction of the axial and joint structure. Researchers appreciate the need of moderate physical exercises, with the objective to minimize the loss caused by Ankylosing Spondylitis in patients. This amount of exercise leads to an inhibition of TFN-alpha as well as the liberation of IL-6. IL-6 is an anti-inflammatory cytosine able to produce other cytokines minimizing the inflammation and to stimulate the liberation of solute TNF-alpha receptors. Thus it contributing to the anti-inflammatory effect of exercise.

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Published
2011-12-27
How to Cite
Paraschiva, C. C., Silva, T. L., & Lima, V. V. B. (2011). The role of physical exercise in the tumor necrosis factor alfa in ankylosing spondylitis carriers. Brazilian Journal of Exercise Prescription and Physiology, 3(13). Retrieved from https://www.rbpfex.com.br/index.php/rbpfex/article/view/141
Issue
Vol. 3 No. 13 (2009)
Section
Scientific Articles - Original

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