Acute and chronic resistant physical exercise with or without supplementation of whey proteins on MTOR gene expression, MURF-1, MAFBX
Abstract
Introduction: Acute and chronic resisted physical exercise is characterized by the performance of short-term repeated series stimuli against resistance, as well as being a potent stimulus to protein synthesis of skeletal muscle. This change in terms of increased skeletal muscle mass depends on the temporal relationship between muscle protein synthesis and muscle protein degradation. The investigation of these pathways is of great importance for the study of skeletal muscle hypertrophy. Studies performed with laboratory animals such as rats or mice have great relevance due to some characteristics such as greater homogeneity of samples and easier control of variables such as training load and especially on caloric intake. In the scientific literature there are several models of acute and chronic physical exercise performed with rats and mice, in addition to supplementation by different protein sources, aiming to evaluate the behavior of these protein synthesis and degradation regulation pathways. Aim: A narrative review of the effects of acute and chronic resistance exercise with or without supplementation on the gene expression of MTOR, MURF-1, MAFBX. Materials and methods: This review was based on the Peres Capes portal; Medline and Lilacs; PubMed; Scielo.org; Scielo.br; Redib; Dialnet Results and discussion: Of the 24 articles reviewed, they were divided into 13 different intervention models. Models separated by time of stimulus: acute or chronic; stimulus type: aerobic, resisted or combined; experimental model and with or without whey protein supplementation. Conclusion: Regarding the study of protein synthesis and degradation pathways, it was possible to observe the use of different experimental models and types of stimulation.
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