The role of glycogen synthase kinase-3 on muscle hypertrophy pathways modulation and the influence of resistance exercise on this signaling

  • Bruno Gil Aldenucci Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Fisioterapeuta e Mestrando do Programa de Biologia Celular e Molecular, na área de concentração de Fisiologia Humana, da Universidade Federal do Paraná
  • Luis Fernando Hoinaski Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Bacharel em Educação Fí­sica pela Pontifí­cia Universidade Católica do Paraná
  • Everson Araújo Nunes Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Doutor pelo Programa de Biologia Celular e Molecular pela Universidade Federal do Paraná
Keywords: Strength exercise, Hypertrophy, Glycogen Synthase Kinase 3, Protein kinase B (Akt)

Abstract

Objective: the objective of this study is to review the influence of glycogen synthase kinase 3 on muscle hypertrophy pathways as the resistance exercise modulation over these pathways. Literature Review: The glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase found in every eukaryotic cell. It regulates several cellular functions, including development, metabolism, gene expression, protein translation, cytoskeleton organization, cell cycle and apoptosis. Furthermore it is a negative regulator of both pathologic and normal growth. Phosphatidilinositol-3-kinase/protein kinase B (also known Akt) pathway inhibits GSK-3. During exercise de Akt activity increases significantly and inhibits GSK-3. The GSK-3 exerts negative influences on transcriptional factors as nuclear factor of activated T cells (NFAT) and β-catenin and on eukaryotic initiation factor 2B (eIF2B). These factors induce protein synthesis andconsequently muscle hypertrophy. Conclusion: Understanding the signaling mechanism which controls skeletal muscle development is important for the treatment of catabolic diseases, neuromuscular disorders, as well as for reducing the duration of rehabilitation period following musculoskeletal trauma.

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Published
2011-12-31
How to Cite
Aldenucci, B. G., Hoinaski, L. F., & Nunes, E. A. (2011). The role of glycogen synthase kinase-3 on muscle hypertrophy pathways modulation and the influence of resistance exercise on this signaling. Brazilian Journal of Exercise Prescription and Physiology, 4(19). Retrieved from https://www.rbpfex.com.br/index.php/rbpfex/article/view/227
Issue
Vol. 4 No. 19 (2010)
Section
Scientific Articles - Original

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