Modulation of NLRP3 Inflammasome by Physical Exercise in Systemic Arterial Hypertension: a scoping Review
Abstract
A modulation of tissue inflammatory processes is widely studied given its relevance in various pathologies, including systemic arterial hypertension (SAH). The NLRP3 complex (NOD-like receptor family, pyrin domain containing 3) activates caspase 1, resulting in the cleavage and activation of important mediators of the inflammatory response, such as interleukins (IL) 1beta and IL-18. Physical exercise, besides being a low-cost and easily accessible therapy for the population, represents an effective form of treatment and prevention for SAH. Recently, there has been a growing interest in studying the relationship between physical exercise and inflammation modulation. However, few studies have investigated the association of the NLRP3 inflammasome with inflammatory processes, including SAH, in response to exercise. Therefore, this study aimed to conduct a comprehensive review to characterize the modulation of the NLRP3 inflammasome through physical exercise in SAH. The methodology adopted followed a protocol based on the Problem, Concept, and Context (PCC) approach, with a search conducted in the PubMed, Cochrane, and LILACS databases, covering the period from October 2020 to 2023. Ten studies that met the inclusion criteria were carefully selected. The results revealed an efficient response in reducing endothelial inflammation with aerobic exercise intervention. The systematization of the information obtained in this study may contribute to the identification of types and protocols of physical activities capable of modulating the inflammatory response and the NLRP3 inflammasome, with potential application in SAH treatment
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