Exercise, uncoupling protein-3 and thermogenesis
Abstract
The mitochondrial uncoupling proteins play an important role in energy metabolism, thus, the gene for UCP-3 can be a good target for research regarding the regulation of body composition in response to physical training. This study aimed to review the scientific evidence related to exercise, uncoupling protein-3 and thermogenesis. Review was made on databases PubMed/MedLine, EBSCOhost, HighWire, Cochrane and Scielo. We identified important resultsabout the effects of aerobic exercise on the expression of UCP-3 acutely, however, the chronic effect of exercise still needs further investigation. Studies with anaerobic exercises are few and divergent as to increased protein expression of UCP-3. Still,there were differences in protein expression of UCP-3, the type of exercise, intensity, volume, duration, whether continuous or interval and in relation to the study design, whether animal or human. Also, there is a dearth of information regarding the relationship between protein expression of UCP-3 with thermogenesis and this in turn with weight control.
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