Glutamine supplementation did not revert exercise immunossupression

  • Luciana Romano Programa de Pós-graduação Lato Sensu em Fisiologia do Exercí­cio da Universidade Gama Filho - UGF
  • Isabela Peixoto Borges Programa de Pós-graduação Lato Sensu em Fisiologia do Exercí­cio da Universidade Gama Filho - UGF
Keywords: Supplementation, Glutamine, Immune system

Abstract

This brief review describes some studies demonstrating that upper respiratory tract infection (U.T.R.I.) is more common in athletes, particularly in periods of intense training and overtraining. The high incidence of the U.R.T.I. among these athletes also presents a association between the chronic exercise training and a reduction in the immune function. Some immune parameters, as the number and activity of thelymphocytes and the natural killer cells), are alterated after endurance exercise. Reduced plasma glutamine levels also have been described in overtraining athletes of different sports. However, although there is clinical evidence supporting the need for exogenous glutamine in the immune system function in critically ill patients, the effectiveness of the glutamine supplementation in endurance athletes is still controversial. This is due to the insufficient evidence that the recuperation of the glutamine plasma levels after exercise is able to reduce infections. Future studies will clarify the role ofthe glutamine or other ergogenic aids in the maintenance and recovery of the athlete’s immune function.

References

- Afrozul, H.; e colaboradores, Changes in peripheral blood lymphocyte subsets associated with marathon running. Med Sci Sports Exerc. 1993; 25: 186-90.

- Antonio, J.; Street, C. Glutamine: a potentially useful supplement for athletes. Can J Appl Physiol. 1999; 24: 1-14.

- Bassit RA, Navarro, F.; e colaboradores, The effect of BCAA supplementation upon the immune response of triathletes. Med Sci Sports Exerc. 2000; 32: 1214-9.

- Blanchard, M.A.; e colaboradores, The influence of diet and exercise on muscle and plasma glutamine concentrations. Med Sci Sports Exerc. 2001; 33: 69-74.

- Borges, V.C.; Duarte, J.S.; Waitzberg, D.L. Imunonutrição: Uma Perspectiva. In: Waitzberg DL. Nutrição Enteral e Parenteral na Prática Clínica. 2ª ed. Rio de Janeiro: Ed. Atheneu, 1995.

- Brenner, I.K.M.; e colaboradores, Stress hormones and the immunological responses to heart and exercise. Int J Sports Med. 1998; 19: 130-43.

- Brenner, I.K.M.; Shek, P.N.; Shephard, R.J. Infection in athletes. Sports Med. 1994; 17: 86-107.

- Bruce, M.; Bowtell, J.L.; Willians, C. Effect oforal glutamine and glucose-polymer supplementation on recovery from exercise. J of Sports Sciences. 2000; 18: 518-9.

- Castell, L.M. Can glutamine modify the apparent immonodepression observed after prolonged, exhaustive exercise? Nutrition. 2002; 18: 371-5.

- Castell, L.M. Some aspects of the acute phase response after a marathon race, and effects of glutamine supplementation. Eur J Appl Physiol. 1997; 75: 47-53.

- Castell, L.M.; Poortmans, J.R.; Newsholme, E.A. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol. 1996; 73: 488-90.

- Castell, L.; Newsholme, E. The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition. 1997; 13: 738-42.

- Ceddia, R.B.; Júnior, J.R.G.; Curi, R. Metabolismo da glutamina no músculo esquelético. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000.

- Colleone, V.V.; e colaboradores. Glutamina sintetase. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000: 65.

- Curi, R. Considerações preliminares. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000: 15-6.

- Curi, R.; Rodrigues Júnior, J.G. Glutamina e exercício. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000: 243-50.

- Eichner, E.R. Overtraining: consequences and prevention. J Sports Sci. 1995; 13: S41-S48.

- Field, C.J.; Johnson, I.; Pratt, V.C. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 2000; 32: S377-S388.

- Friman, G.; Ilback, N.G. Exercise and infection – interaction, risks and benefits. Scand J Med Sci Sports. 1992; 2: 177-89.

- Gleeson, M.; e colaboradores. The effect of severe eccentric exercise-induced muscle damage on plasma elastase, glutamine and zinc concentrations. Eur J Appl Physiol. 1998; 77: 543-6.

- Gleeson, M.; e colaboradores. Effect of low and high-carbohydrate diets on the plasma glutamine and circulating leukocytes responses to exercise. Int J Sport Nutr. 1998; 8: 49-59.

- Gleeson, M.; Bishop, N.C. Elite athlete immunology: importance of nutrition. Int J Sports Med. 2000; 21: S44-S50.

- Hiscock, N.; Mackinnon, L.T. A comparison of plasma glutamine concentration in athletes from different sports. Med Sci Sports Exerc. 1998; 30: 1693-96.

- Kapadia, C.R.; e colaboradores. Maintenance of skeletal muscle intracellular glutamine during standard surgical trauma. JPEN. 1985; 9: 583-9.

- Keast, D.; e colaboradores, Depression of plasma glutamine concentration after exercise stress and its possible influence on the immune system. Med J Aust. 1995; 162: 15-8.

- Kreider, R.B. Dietary supplements and the promotion of muscle growth with resistence exercise. Sports Med. 1999; 27: 97-110.

- Maclean, D.A.; Graham, T.E.; Sattin, B. Stimulation of muscle ammonia production during exercise following branched-chain amino acid supplementation in humans. J Physiol. 1996; 15: 909-22.

- Mackinnon, L.T. Chronic exercise training effects on immune function. Med Sci Sports Exerc. 2000; 32: S369-S376.

- Mackinnon, L.T.; Hooper, S.L. Plasma glutamine and upper respiratory tract infection during intensified training in swimmers. éd Sci Sports Exerc. 1996; 28: 285-90.

- Marzzoco, A, Torres BB. Bioquímica básica. 2ª ed. Ed. Guanabara Koogan: Rio de Janeiro, 1999.

- Maughan, R.; Gleeson, M.; Greenhaff, P.L. Bioquímica do Exercício e do Treinamento. Ed. Manole: São Paulo, 2000.

- Melo, R.F.; e colaboradores, Formas químicas de administração de glutamina. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000: 257.

- Mckenzie, D.C.; Markers of Excessive Exercise. Can J Appl Physiol.1999; 24: 66-73.

- Nieman, D.C. Is infection risk linked to exercise workload? Med Sci Sports Exerc. 2000. 32: S406-S411.

- Nieman, D.C. Exercise immunology: future directions for research related to athletes, nutrition, and the elderly. Int J Sports Med. 2000; 21: S61-S68.

- Nieman, D.C.; Pedersen, B.K. Exercise and immune function. Recent developments. Sports Med. 1999; 27: 73-80.

- Nieman, D.C. Exercise, upper respiratory tract infection, and the immune system. Med Sci Sports Exerc. 1994; 26: 128-39.

- Newsholme, E.A. Biochemical mechanisms to explain immunosuppression in well-trained and overtrained athletes. Int J Sports Med. 1994; 15: S142-S147.

- Newsholme, E.A.; Parry-Billings, M. Properties of glutamine release from muscle and its importance for the immune system. JPEN. 1990; 14: S63-S67.

- Parry-Billings, M. e colaboradores. Plasma amino acid concentration in the overtraining syndrome:possible effects on the immune system. Med Sci Sports Exe. 1992; 24: 1353-8.

- Parry-Billings, M.; e colaboradores. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med. 1990; 11: S122-S128.

- Parry-Byllings, M.; e colaboradores. Does glutamine contribute to immunosuppression after major burns? Lancet. 1990; 336: 523-5.

- Palanch, A.C. Metabolismo da glutamina no intestino. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000.

- Pedersen, B.K.; Toft, A.D. Effects of exercise on lymphocytes and cytokines. Br J Sports Med. 2000; 34: 246-51.

- Pedersen, B.K.; e colaboradores. Exercise and immune system – influence of nutrition and ageing. J of Science and Med in Sport. 1999; 2: 234-52.

- Petibois, Cyril.; e colaboradores. Biochemical aspects of overtraing in endurance sports. Sports Méd. 2002; 32: 867-78.

- Pompéia, C. Glutaminase. In: Curi R. Glutamina: metabolismo e aplicações clínicas e no esporte. Rio de Janeiro: Ed. Sprint, 2000:17.

- Robson, P.J.; e colaboradores. Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med. 1999; 20: 128-35.

- Rohde, T.; e colaboradores. The immune system and serum glutamine during a triathlon. Eur J Appl Physiol. 1996; 74: 428-34.

- Rohde, T.; e colaboradores. Effects of glutamine on the immune system – influence of muscular exercise and HIV infection. J Appl Physiol. 1995; 79: 146-50.

- Rohde, T.; Maclean, D.A.; Pedersen, B.K. Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med Sci Sports Exerc. 1998; 78: 448-53.

- Rohde, T.; Maclean, D.A.; Pedersen, B.K. Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med Sci Sports Exerc. 1998; 30: 856-62.

- Rohde, T.; Krywkowski, K.; Pedersen, B.K. Glutamine, exercise, and the immune system – is there a link? Exerc Immunol Rev. 1998; 4: 4-49.

- Rowbottom, D.G.; e colaboradores. Training adaptation and biological changes among well-trained male triathletes. Med Sci Sports Exerc. 1997; 29: 1233-9.

- Rowbottom, D.G.; Green, K.J. Acute exercise effects on the immune system. Med Sci Sports Exerc. 2000; 32: S396-S405.

- Rowbottom, D.G.; Keast, D.; Morton, A.R. The emerging role of glutamine as an indicator of exercise stress and overtraing. Sports Med. 1996. 21: 80-97.

- Smith, D.J.; Norris, S.R. Changes in glutamine and glutamate concentrations fot tracking training tolerance. Med Sci Sports Exerc. 2000; 32: 684-9.

- Smith, R.J.; Wilmore, D. Glutamine nutrition and requirements. JPEN. 1990; 14: S94-S99.

- Van Hall, G.; Saris, W.H.M.; Wagenmakers, A.J.M. Effect of carbohydrate supplementation on plasma glutamine during prolonged exercise and recovery. Int J Sports Med. 1998; 19: 82-86.

- Wagenmarkers, A.J.M. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exer Sport Sci Rev. 1998; 26: 287-314.

- Waitzberg, D.L.; Lagullo, P. Proteínas. In: Waitzberg DL. Nutrição Enteral e Parenteral na Prática Clínica. 2ª ed. Rio de Janeiro: Ed. Atheneu, 1995.

- Walsh, N.P.; e colaboradores. Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int J Sport Nutr Exerc Metab. 2000; 10: 39-50.

Published
2007-02-04
How to Cite
Romano, L., & Borges, I. P. (2007). Glutamine supplementation did not revert exercise immunossupression. Brazilian Journal of Exercise Prescription and Physiology, 1(1). Retrieved from https://www.rbpfex.com.br/index.php/rbpfex/article/view/7
Section
Scientific Articles - Original