La participación de la glucógeno sintasa quinasa 3 en la modulación de las vías hipertróficas musculares y las influencias que ejerce el ejercicio de fuerzas en estas señales

  • Bruno Gil Aldenucci Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Fisioterapeuta e Mestrando do Programa de Biologia Celular e Molecular, na área de concentração de Fisiologia Humana, da Universidade Federal do Paraná
  • Luis Fernando Hoinaski Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Bacharel em Educação Fí­sica pela Pontifí­cia Universidade Católica do Paraná
  • Everson Araújo Nunes Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Doutor pelo Programa de Biologia Celular e Molecular pela Universidade Federal do Paraná
Palabras clave: Ejercicio de fuerza, Hipertrofia, Glucógeno Sintasa Quinasa 3, Proteína quinasa B (Akt)

Resumen

Objetivo: El objetivo de este trabajo es revisar las influencias de la Glucógeno Sintasa Quinasa 3 en la modulación de las vías musculares hipertróficas ejercidas por el ejercicio de fuerza. Revisión de la literatura: la glucógeno sintasa quinasa 3 (GSK-3) es una serina/treonina presente en todos los eucariotas. Regula varias funciones celulares, incluido el desarrollo, el metabolismo, la expresión génica, la traducción de proteínas, la organización del citoesqueleto, la regulación del ciclo celular y la apoptosis. Además, es un regulador negativo tanto del crecimiento patológico como normal. Es inhibido por vías como la fosfatidilinositol-3-quinasa/proteína quinasa B (también llamada Akt). Durante el ejercicio físico, la actividad de Akt aumenta significativamente, inhibiendo la GSK-3. GSK-3 ejerce una influencia negativa sobre factores transcripcionales como: factor nuclear de células T activadas (NFAT), β-catenina y factor de iniciación eucariota 2B (eIF2B), que estimulan la síntesis de proteínas y la consiguiente hipertrofia muscular. Conclusión: La comprensión de los mecanismos de señalización que controlan el desarrollo del músculo esquelético ayuda en la formación de tratamientos para enfermedades catabólicas, trastornos neuromusculares y también puede reducir el tiempo de rehabilitación después de un trauma musculoesquelético.

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Publicado
2011-12-31
Cómo citar
Aldenucci, B. G., Hoinaski, L. F., & Nunes, E. A. (2011). La participación de la glucógeno sintasa quinasa 3 en la modulación de las vías hipertróficas musculares y las influencias que ejerce el ejercicio de fuerzas en estas señales. Revista Brasileña De Prescripción Y Fisiología Del Ejercicio, 4(19). Recuperado a partir de https://www.rbpfex.com.br/index.php/rbpfex/article/view/227
Número
Vol. 4 Núm. 19 (2010)
Sección
Artículos Científicos - Originales

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