La partecipazione della glicogeno sintasi chinasi 3 alla modulazione delle vie ipertrofiche muscolari e le influenze esercitate dall'esercizio delle forze in questi segnali

  • Bruno Gil Aldenucci Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Fisioterapeuta e Mestrando do Programa de Biologia Celular e Molecular, na área de concentração de Fisiologia Humana, da Universidade Federal do Paraná
  • Luis Fernando Hoinaski Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Bacharel em Educação Fí­sica pela Pontifí­cia Universidade Católica do Paraná
  • Everson Araújo Nunes Programa de Pós Graduação Lato Sensu da Universidade Gama Filho em Fisiologia do Exercí­cio: Prescrição de Exercí­cio. Doutor pelo Programa de Biologia Celular e Molecular pela Universidade Federal do Paraná
Parole chiave: Esercizio di forza, Ipertrofia, Glicogeno sintase chinasi 3, Proteina chinasi B (Akt)

Abstract

Obiettivo: L'obiettivo di questo lavoro è rivedere le influenze della glicogeno sintasi chinasi 3 nella modulazione delle vie ipertrofiche muscolari esercitate dall'esercizio di forza. Revisione della letteratura: la glicogeno sintasi chinasi 3 (GSK-3) è una serina/treonina presente in tutti gli eucarioti. Regola varie funzioni cellulari, tra cui lo sviluppo, il metabolismo, l'espressione genica, la traduzione delle proteine, l'organizzazione del citoscheletro, la regolazione del ciclo cellulare e l'apoptosi. Inoltre, è un regolatore negativo della crescita sia patologica che normale. È inibito da percorsi come la fosfatidilinositolo-3-chinasi/proteina chinasi B (chiamata anche Akt). Durante l'esercizio fisico, l'attività di Akt aumenta significativamente, inibendo GSK-3. GSK-3 esercita un'influenza negativa su fattori trascrizionali quali: fattore nucleare delle cellule T attivate (NFAT), β-catenina e fattore di iniziazione eucariotica 2B (eIF2B), che stimolano la sintesi proteica e la conseguente ipertrofia muscolare. Conclusione: la comprensione dei meccanismi di segnalazione che controllano lo sviluppo del muscolo scheletrico aiuta nella formazione di trattamenti per malattie cataboliche, disturbi neuromuscolari e può anche ridurre il tempo di riabilitazione dopo un trauma muscoloscheletrico.

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Pubblicato
2011-12-31
Come citare
Aldenucci, B. G., Hoinaski, L. F., & Nunes, E. A. (2011). La partecipazione della glicogeno sintasi chinasi 3 alla modulazione delle vie ipertrofiche muscolari e le influenze esercitate dall’esercizio delle forze in questi segnali. Giornale Brasiliano Di Prescrizione E Fisiologia dell’esercizio, 4(19). Recuperato da https://www.rbpfex.com.br/index.php/rbpfex/article/view/227
Fascicolo
V. 4 N. 19 (2010)
Sezione
Articoli scientifici - Originali

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